| Year | Film | Role |
| 1996 | A Couch in New York | Henry Harriston |
| 2005 | A History of Violence | Richie Cusack |
| 1988 | A Time of Destiny | Martin Larraneta |
| 2001 | A.I. Artificial Intelligence | Professor Allen Hobby |
| 1990 | Alice | Doug Tate |
| 1980 | Altered States | Professor Edward Jessup |
| 2007 | Beautiful Ohio | Simon Messerman |
| 1981 | Body Heat | Ned Racine |
| 1987 | Broadcast News | Tom Grunick |
| 2002 | Changing Lanes | Doyle Gipson’s AA Sponsor |
| 1986 | Children of a Lesser God | James Leeds |
| 2000 | Contaminated Man | David R. Whitman |
| 2009 | Damages | Daniel Purcell |
| 1998 | Dark City | Inspector Frank Bumstead |
| 1999 | Do Not Disturb | Walter Richmond |
| 2009 | Endgame | Willie Esterhuyse |
| 1981 | Eyewitness | Daryll Deever |
| 2000 | Frank Herbert’s Dune | Duke Leto Atreides |
| 2004 | Frankenstein | Professor Waldman |
| 1983 | Gorky Park | Arkady Renko |
| 1990 | I Love You to Death | Harlan James |
| 2007 | Into the Wild | Walt McCandless |
| 1996 | Jane Eyre | Rochester |
| 2002 | King of Queens | Dr. Taber |
| 1985 | Kiss of the Spider Woman | Luis Alberto Molina |
| 1998 | Lost in Space | Professor John Robinson |
| 2002 | Master Spy: The Robert Hanssen Story | Robert Hanssen |
| 1996 | Michael | Frank Quinlan |
| 2007 | Mr. Brooks | Marshall |
| Mr. Wonderful | Tom | |
| Neverwas | Dr. Peter Reed | |
| 2006 | Nightmares and Dreamscapes: From the Stories of Stephen King | Jason Renshaw |
| 2007 | Noise | Mayor Schneer |
| 1998 | One True Thing | George Gulden |
| 2001 | Rare Birds | Restaurateur |
| 2010 | Robin Hood | William Marshal |
| 1994 | Second Best | Graham Holt |
| 1995 | Smoke | Paul Benjamin |
| 1999 | Sunshine | Andor Knorr |
| Syriana | Stan Goff | |
| 1999 | The 4th Floor | Greg Harrison |
| 1988 | The Accidental Tourist | Macon Leary |
| 1999 | The Big Brass Ring | William Blake Pellarin |
| 1983 | The Big Chill | Nick |
| 2004 | The Blue Butterfly | Alan Osborne |
| 2009 | The Countess | Gyorgy Thurzo |
| 1991 | The Doctor | Dr. Jack MacKee |
| 2006 | The Good Shepherd | CIA Director Philip Allen |
| 2008 | The Incredible Hulk | General Thaddeus “Thunderbolt” Ross |
| 2005 | The King | David |
| 2006 | The Legend of Sasquatch | John Davis |
| 2000 | The Miracle Maker | Jairus |
| 1993 | The Plague | Doctor Bernard Rieux |
| 2009 | The River Why | H2O |
| 2001 | The Simian Line | Edward |
| 2004 | The Village | Edward Walker |
| 2008 | The Yellow Handkerchief | Brett Hanson |
| 2002 | Tuck Everlasting | Angus Tuck |
| 1991 | Until the End of the World | Sam Farber, alias Trevor McPhee |
| 2008 | Vantage Point | President Ashton |
| 2001 | Varian’s War | Varian Fry |
| 1978 | Verna: U.S.O. Girl | Walter |