| Year | Film | Role |
| 1992 | Lorenzo’s Oil | Young Teacher |
| 1993 | Dave | Randi |
| 1993 | Class of ’61 | Lily Magraw |
| 1993 | Tales of the City | Mary Ann Singleton |
| 1993 | Searching for Bobby Fischer | School Teacher |
| 1993 | Blind Spot | Phoebe |
| 1994 | Law & Order (Episode “Blue Bamboo”) | Martha Bowen |
| 1994 | A Simple Twist of Fate | Nancy Lambert Newland |
| 1995 | Congo | Dr. Karen Ross |
| 1996 | Primal Fear | Janet Venable |
| 1997 | Absolute Power | Kate Whitney |
| 1998 | The Truman Show | Meryl Burbank/Hannah Gill |
| 1998 | More Tales of the City | Mary Ann Singleton |
| 1999 | Love Letters | Melisa Gardner Cobb |
| 1999 | Lush | Rachel Van Dyke |
| 2000 | The House of Mirth | Bertha Dorset |
| 2000 | You Can Count on Me | Samantha ‘Sammy’ Prescott |
| 2000 | Maze | Callie |
| 2000 | Running Mates | Lauren Hartman |
| 2001 | Wild Iris | Iris Bravard |
| 2001 | Further Tales of the City | Mary Ann Singleton |
| 2002 | The Mothman Prophecies | Officer Connie Mills |
| 2002 | The Laramie Project | Sherry Johnson |
| 2003 | The Life of David Gale | Constance Harraway |
| 2003 | Mystic River | Annabeth Markum |
| 2003 | Love Actually | Sarah |
| 2003 | Frasier | Mindy (1 episode, voice) |
| 2004 | Kinsey | Clara McMillen |
| 2004 | P.S. | Louise Harrington |
| 2005 | The Exorcism of Emily Rose | Erin Bruner |
| 2005 | The Squid and the Whale | Joan Berkman |
| 2006 | Jindabyne | Claire |
| 2006 | Driving Lessons | Laura Marshall |
| 2006 | Man of the Year | Eleanor Green |
| 2006 | The Hottest State | Jesse |
| 2007 | Breach | Kate Burroughs |
| 2007 | The Savages | Wendy Savage |
| 2007 | The Nanny Diaries | Mrs. X |
| 2008 | John Adams | Abigail Adams |
| 2008 | The City of Your Final Destination | Caroline |
| 2008 | The Other Man | Lisa |
| 2009 | Morning | |
| 2009 | Sympathy for Delicious | Nina Hogue |
| 2010 | The Details | Lila |
| 2010 | The Big C | Cathy Jamison |