| 2010 | You Don’t Know Jack | Dr. Jack Kevorkian |
| 2010 | Wilde Salome | Himself / King Herod |
| 2008 | Righteous Kill | Detective David “Rooster” Fisk |
| 2007 | Ocean’s Thirteen | Willie Bank |
| 2007 | 88 Minutes | Dr. Jack Gramm |
| 2005 | Two for the Money | Walter Abrams |
| 2004 | Merchant of Venice, TheThe Merchant of Venice | Shylock |
| 2003 | Recruit, TheThe Recruit | Walter Burke |
| 2003 | Gigli | Starkman |
| 2003 | Angels in America | Roy Cohn |
| 2002 | Insomnia | Will Dormer |
| 2002 | S1m0ne | Viktor Taransky |
| 2002 | People I Know | Eli Wurman |
| 2000 | Chinese Coffee | Harry Levine |
| 1999 | Insider, TheThe Insider | Lowell Bergman |
| 1999 | Any Given Sunday | Tony D’Amato |
| 1997 | Donnie Brasco | Benjamin ‘Lefty’ Ruggiero |
| 1997 | Devil’s Advocate, TheThe Devil’s Advocate | John Milton |
| 1996 | Looking for Richard | Director/Narrator/Richard III |
| 1996 | City Hall | John Pappas |
| 1995 | Two Bits | Gitano Sabatoni |
| 1995 | Heat | Lt. Vincent Hanna |
| 1993 | Carlito’s Way | Carlito ‘Charlie’ Brigante |
| 1992 | Glengarry Glen Ross | Ricky Roma |
| 1992 | Scent of a Woman | Frank Slade |
| 1991 | Frankie and Johnny | Johnny |
| 1990 | Local Stigmatic, TheThe Local Stigmatic | Graham |
| 1990 | Dick Tracy | Alphonse “Big Boy” Caprice |
| 1990 | Godfather Part III, TheThe Godfather Part III | Michael Corleone |
| 1989 | Sea of Love | Frank Keller |
| 1985 | Revolution | Tom Dobb |
| 1983 | Scarface | Tony Montana |
| 1982 | Author! Author! | Ivan Travalian |
| 1980 | Cruising | Steve Burns |
| 1979 | And Justice for All …And Justice for All | Arthur Kirkland |
| 1977 | Bobby Deerfield | Bobby Deerfield |
| 1975 | Dog Day Afternoon | Sonny Wortzik |
| 1974 | Godfather Part II, TheThe Godfather Part II | Michael Corleone |
| 1973 | Scarecrow | Francis Lionel ‘Lion’ Delbuchi |
| 1973 | Serpico | Frank Serpico |
| 1972 | Godfather, TheThe Godfather | Michael Corleone |
| 1971 | Panic in Needle Park, TheThe Panic in Needle Park | Bobby |
| 1969 | Me, Natalie | Tony |